| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261307 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2012 | 10 Pages |
Abstract
⺠Alkaptonuria (no therapy) is a novel type II secondary amyloidosis. ⺠Ochronotic melanin-based pigment and SAA/SAP amyloid co-localize in Alkaptonuria. ⺠High levels of SAA and SAP were found in AKU patients' plasma. ⺠Systemic amyloidosis was assessed in patients' abdominal fat and salivary gland. ⺠Methotrexate reduces (- 97%) HGA-induced A-amyloid aggregates.
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Authors
Lia Millucci, Adriano Spreafico, Laura Tinti, Daniela Braconi, Lorenzo Ghezzi, Eugenio Paccagnini, Giulia Bernardini, Loredana Amato, Marcella Laschi, Enrico Selvi, Mauro Galeazzi, Alessandro Mannoni, Maurizio Benucci, Pietro Lupetti, Federico Chellini,