| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261310 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2012 | 11 Pages |
Abstract
⺠Exercise training improved glucose tolerance in insulin-resistant mice. ⺠Exercise training induced an elevated AMPK and decreased mTOR/S6K1 activity. ⺠Activation of AMPK inhibited Akt and S6K1 phosphorylation in C2C12 cells. ⺠S6K1 is responsible for the inhibition of SREBP1 by AMPK in C2C12 myotubes. ⺠Our data suggest that exercise training inhibits SREBP-1 through AMPK/mTOR pathway.
Keywords
AMPKp70 ribosomal protein S6 kinase 1ACCNEFASREBP-1cCPT14E-BP1mTORLCFAS6K1AMP-activated protein kinaseFAT/CD36Aktacetyl-CoA carboxylaseLong-chain fatty acidsnon-esterified fatty acidsfatty acid translocaseWhite adipose tissueAerobic exercisediacylglycerolDAGhigh-fat dietInsulin signalingLipogenesisInsulin resistancemammalian target of rapamycinSterol regulatory element binding protein 1cprotein kinase BWATCarnitine palmitoyltransferase I
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Authors
Xiaolei Liu, Hairui Yuan, Yanmei Niu, Wenyan Niu, Li Fu,