| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261326 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2012 | 11 Pages |
Abstract
⺠Mutated AβPP increases oxidative stress and remodels the proteolysis in an AD model. ⺠Alterations in the autophagic flux are evident at the step of autophagosome formation. ⺠Cells try to counteract the altered scenario activating the HDAC6-dependent autophagy. ⺠Existence of an Aβ42 level beyond which proteolysis becomes definitely dysfunctional
Keywords
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Authors
Valentina Cecarini, Laura Bonfili, Massimiliano Cuccioloni, Matteo Mozzicafreddo, Giacomo Rossi, Laura Buizza, Daniela Uberti, Mauro Angeletti, Anna Maria Eleuteri,