| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261328 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2012 | 11 Pages |
Abstract
⺠The K161N variant of human GALE is more resistant to denaturation ⺠K161N has very low detectable NAD+ and greatly reduced enzymatic activity ⺠The D175N variant is less stable and slightly less active than the wild type ⺠GALE's activities with UDP-Gal and UDP-GalNAc are not necessarily correlated
Keywords
uridine diphosphate galactoseUDP-GalUDP-GlcBS3UDP-GlcNAcUDP-GalNacGuHClUDP-galactose 4′-epimeraseNAD(H)NAD+Förster resonance energy transferFREToxidized nicotinamide adenine dinucleotideGalEANSDifferential scanning fluorimetryYeast modelNADHreduced nicotinamide adenine dinucleotideuridine diphosphate glucoseGuanidine hydrochloride
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Authors
Thomas J. McCorvie, Ying Liu, Andrew Frazer, Tyler J. Gleason, Judith L. Fridovich-Keil, David J. Timson,