| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261351 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2012 | 9 Pages |
Abstract
⺠Presence of m.14484T>C in a Chinese family with essential hypertension but no LHON. ⺠The arterial stiffness of members carrying m.14484T>C was significantly increased. ⺠m.14484T>C caused mitochondrial dysfunction in cells from affected members. ⺠Mitochondrial DNA mutation is involved in essential hypertension. ⺠Patients with primary LHON mutation should undergo evaluation of blood pressure.
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Authors
Hao Guo, Xin-Ying Zhuang, A-Mei Zhang, Wen Zhang, Yong Yuan, Li Guo, Dandan Yu, Juan Liu, Da-Kuan Yang, Yong-Gang Yao,