| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261385 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2012 | 13 Pages |
Abstract
⺠We identified the specific peptide inhibitor of mitochondrial μ-calpain. ⺠We intravitreally injected the peptide into an animal model of retinitis pigmentosa. ⺠The peptide prevented retinal photoreceptor apoptosis and preserved retinal function. ⺠Eye drops containing the peptide also inhibited photoreceptor apoptosis. ⺠The peptide offers a new modality for treating retinitis pigmentosa.
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Authors
Taku Ozaki, Mitsuru Nakazawa, Tetsuro Yamashita, Hiroyuki Sorimachi, Shoji Hata, Hiroshi Tomita, Hitomi Isago, Ayaka Baba, Sei-ichi Ishiguro,