| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261387 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2012 | 8 Pages |
Abstract
⺠Molecular mechanism of tropomyosin-related congenital myopathies is proposed. ⺠Tropomyosin mutants affect assembly and regulation of actin thin filaments. ⺠A decrease of Ca-dependent activation of actomyosin is common in all myopathies. ⺠Ca- and myosin-induced activation is required for normal actin motility. ⺠Mutations located in the central tropomyosin region have the most severe effects.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Katarzyna Robaszkiewicz, Elżbieta Dudek, Andrzej A. Kasprzak, Joanna Moraczewska,