| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261417 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2012 | 11 Pages |
Abstract
⺠Fatty acids decrease SIRT1 expression in β cells. ⺠Resveratrol ameliorates palmitate-suppressed insulin secretion. ⺠Knockdown or inhibition of SIRT1 suppresses insulin transcription. ⺠SIRT1 activation ameliorates palmitate-inhibited insulin promoter activity.
Keywords
Sirt1JnkNkx6.1FFAMafAGSISPdx1sirtuin 1AMPKPGC-1Jun N-terminal kinaseAMP-activated protein kinasePancreatic and duodenal homeobox 1neuroDβ-CellFree fatty acidGlucose-stimulated insulin secretionneurogenic differentiationLipotoxicitypalmitateperoxisome proliferator-activated receptor gamma coactivator 1
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Authors
Ling Wu, Libin Zhou, Yan Lu, Juan Zhang, Fangfang Jian, Yun Liu, Fengying Li, Wenyi Li, Xiao Wang, Guo Li,