| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261428 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2012 | 9 Pages |
Abstract
⺠Anti-atherogenic cytokine TGF-β inhibits macrophage foam cell formation. ⺠The role of Smads in the control of macrophage cholesterol homeostasis was studied. ⺠Smads were found to play a key role in the TGF-β-mediated uptake of modified LDL. ⺠A dominant role of Smad2 was identified in the regulation of gene expression. ⺠The TGF-β-Smad axis may represent a powerful anti-foam cell therapeutic target.
Keywords
THP-1Human acute monocytic leukemia cell lineTGF-βABCA-1SR-AHMDMapolipoprotein E deficientoxLDLLPLAcLDLCD36shRNAApoE−/−DiIshort hairpin RNAAtherosclerosisApoeapolipoprotein Ecluster of differentiation 36Foam cellLipoprotein lipaseacetylated low density lipoproteinoxidized low density lipoproteinlow density lipoproteinLDLMacrophagehuman monocyte-derived macrophagescholesterolScavenger receptor A
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Authors
Daryn R. Michael, Rebecca C. Salter, Dipak P. Ramji,