Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease

Article ID	Journal	Published Year	Pages	File Type
8261441	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	2012	9 Pages	PDF

Abstract

âº scyllo-Inositol (SI) rescues autophagic vacuole accumulation in TgCRND8 mice. âº SI rescues abnormalities in the latter stages of autophagy in TgCRND8 mice. âº Autophagy rescue may be a mechanism of action for SI-amyloid-Î² interaction.

Keywords

Aβ AmC APP AMPA NBT PFA HRP TBS β-CTF mTOR Autophagic vacuole HAV TgCRND8 FITC SDS PBS CATD Scyllo-inositol CatB 7-amino-4-methyl-coumarin nitroblue tetrazolium Autophagy EDTA Ethylenediaminetetraacetic acid Alzheimer disease analysis of variance ANOVA Tris-buffered saline Min minute Hour sodium dodecyl sulfate Lysosome Phosphate-buffered saline mammalian target of rapamycin paraformaldehyde Horseradish peroxidase amyloid precursor protein amyloid-beta peptide Cathepsin B cathepsin D LAV