Inhibitory effect of curcumin on the Al(III)-induced AÎ²42 aggregation and neurotoxicity in vitro

Article ID	Journal	Published Year	Pages	File Type
8261479	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	2012	9 Pages	PDF

Abstract

âº Al(III) promotes AÎ²42 fibrillation, leading to the high neurotoxicity to PC12 cells. âº Curcumin is able to inhibit the formation of Al(III)-induced AÎ²42 fibrillation. âº Al(III)-curcumin complexes can remold the AÎ²42 fibrils into amorphous aggregates.

Keywords

AFM CBB HFIP Aβ42 hexafluoroisopropanol Coomassie Brilliant Blue Al(III)ThT Alzheimer's disease Thioflavin T circular dichroism Protein conformation Aggregate morphology atomic force microscopy Aluminum ion