| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261527 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2012 | 11 Pages |
Abstract
⺠The calcium sensor hippocalcin is deregulated in Alzheimer's disease hippocampus. ⺠In APP mutant mice, hippocalcin levels are increased. ⺠In these mice, hippocampal neurons that are high in Abeta are low in hippocalcin. ⺠Hippocampal neurons from hippocalcin KO mice are sensitive to calcium deregulators. ⺠Cortical neurons from hippocalcin KO mice show sensitivity similar to wild-type. ⺠Hippocalcin knock-out neurons show an age-dependent mitochondrial deregulation.
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Authors
Yun-An Lim, Maria Giese, Claire Shepherd, Glenda Halliday, Masaaki Kobayashi, Ken Takamatsu, Matthias Staufenbiel, Anne Eckert, Jürgen Götz,