| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261539 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2012 | 14 Pages |
Abstract
âºWe examine the mechanism of increased β-secretase processing of APP in NPC1â/â cells. âºAPP internalization is prerequisite for increased Aβ/APP-CTF levels in NPC1â/â cells. âºUpon NPC1-loss APP and BACE1 (β-secretase) sequester within endocytic vesicles. âºCholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1â/â cells. âºCholesterol modulates Alzheimer's disease by altering trafficking of APP and BACE1.
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Authors
Martina Malnar, Marko Kosicek, Ana Lisica, Melanija Posavec, Ana Krolo, Jasenka Njavro, Damir Omerbasic, Sabina Tahirovic, Silva Hecimovic,