Prolongation of carrageenan-induced inflammation in human colonic epithelial cells by activation of an NFÎºBâBCL10 loop

Article ID	Journal	Published Year	Pages	File Type
8261569	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	2012	8 Pages	PDF

Abstract

âº Exposure to common food additive carrageenan initiates protracted inflammation. âº The presence of NF-ÎºB binding site in the BCL10 promoter sets up inflammatory loop. âº Both RelA and RelB bind to the NF-ÎºB binding site in the BCL10 promoter. âº In contrast to carrageenan, DSS exposure does not initiate prolonged inflammation.

Keywords

CGN NFE CARMA NF-κB inducing kinase NIK BCL10 NF-kappaB IL-8 TLR4 IKK IκB Hsp NF-κB CBM CAPE DSS ROS inflammation Interleukin-8 Mucosa-associated lymphoid tissue Dextran sulfate sodium IRAK Platelet-activating factor nuclear factor kappaB Malt inhibitor of κB PAF heat-shock protein CHiP Carrageenan Reactive oxygen species Toll-like receptor 4 Ubiquitin