| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261594 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2012 | 11 Pages |
Abstract
⺠Both TGF-β and acetylcholine increase in induced sputum during airway inflammation of COPD. ⺠TGF-β increases expression of muscarinic receptors and choline acetyltransferase in epithelial cells. ⺠ACh promotes neutrophil adhesion to epithelial cells targeting muscarinic receptors. ⺠TGF-β and ACh interact to promote neutrophilic inflammation in the airways. ⺠β2 long-acting and anticholinergic drugs might control TGF-β and ACh neutrophilic airway inflammation in COPD.
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Authors
Mirella Profita, Anna Bonanno, Angela Marina Montalbano, Giusy Daniela Albano, Loredana Riccobono, Liboria Siena, Maria Ferraro, Paola Casarosa, Michael Paul Pieper, Mark Gjomarkaj,