Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8261639 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2012 | 11 Pages |
Abstract
⺠Stargardt's disease is associated with mutations in Abca4 and causes macular degeneration. ⺠We use the Abca4â/â/Nrlâ/â double knockout mouse to model Stargardt's disease. ⺠We show that cones accumulate more toxic A2E per mole of retinoid than rods. ⺠We also show that cones lacking Abca4 are less effective at clearing A2E than rods. ⺠These data suggest that cones are more sensitive to the loss of Abca4 than rods.
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Authors
Shannon M. Conley, Xue Cai, Rasha Makkia, Yalin Wu, Janet R. Sparrow, Muna I. Naash,