| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261669 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2011 | 8 Pages |
Abstract
⺠ER stress impairs MHC-I surface expression in thyroid cells. ⺠Thyroid cells undergoing ER stress are more susceptible to NK-mediated lysis. ⺠Thyroid cells undergoing ER stress stimulate INF-γ production by NK cells. ⺠These results suggest a possible new role of ER stress and NK activation in thyroid autoimmunity.
Keywords
GRP94HFEtunicamycinERADHLA-IXBP-1IFN-γIL-2UPRPDIMHC-IThapsigarginnatural killerThyroid autoimmunityBiPER associated degradationER stressinterferon-γInterleukin-2Natural killer cellsendoplasmic reticulumUnfolded protein responseX-box binding protein 1protein disulfide isomeraseMajor histocompatibility complex class IGlucose regulated protein 94
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Authors
L. Ulianich, G. Terrazzano, M. Annunziatella, G. Ruggiero, F. Beguinot, B. Di Jeso,