Biliverdin reductase-A protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment

Article ID	Journal	Published Year	Pages	File Type
8261716	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	2011	8 Pages	PDF

Abstract

âº Increased biliverdin reductase (BVR) expression in AD and MCI hippocampus. âº Decreased phosphorylations (pSer/Thr and pTyr) on BVR in AD and MCI hippocampus. âº Decrease in BVR phosphorylation was associated with reduced activity. âº No change were observed in cerebellum, which lacks pathology in AD and MCI.

Keywords

BVR Phospho-tyrosine pTyr mild cognitive impairment biliverdin reductase Alzheimer disease Oxidative stress Cerebellum MCI heme oxygenase Hippocampus

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Life Sciences Biochemistry, Genetics and Molecular Biology Ageing

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Biliverdin reductase-A protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment

Authors

Eugenio Barone, Fabio Di Domenico, Giovanna Cenini, Rukhsana Sultana, Chiara Cini, Paolo Preziosi, Marzia Perluigi, Cesare Mancuso, D. Allan Butterfield,