| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261729 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2011 | 12 Pages |
Abstract
⺠This work describes the molecular mechanism of lipid induced insulin resistance. ⺠Fatty acid (FA) downregulates insulin receptor expression in insulin target cells. ⺠FA phosphorylates PKCε (pPKCε) that adversely affects insulin receptor (IR). ⺠pPKCε impairs HMGA1, the transcription regulator of IR gene. ⺠Reduced IR expression due to FA abrogates insulin sensitivity.
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Authors
Suman Dasgupta, Sushmita Bhattacharya, Sudipta Maitra, Durba Pal, Subeer S. Majumdar, Asis Datta, Samir Bhattacharya,