| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261812 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2011 | 7 Pages |
Abstract
ⶠThe pro-inflammation cytokine, TNF-alpha, impairs the Hypocretin/Orexin system. ⶠTNF-alpha decreases the expression of Prepro-Hypocretin and Hypocretin receptor 2. ⶠTNF-alpha increases mRNA degradation and ubiquitination of the Hypocretin system. ⶠImpaired Hypocretin system contributes to the development of sleep disorders. ⶠTNF-alpha may regulate the sleep-wake cycle through the Hypocretin system.
Keywords
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Authors
Shuqin Zhan, Guo-Qiang Cai, Anni Zheng, Yuping Wang, Jianping Jia, Haotian Fang, Youfeng Yang, Meng Hu, Qiang Ding,