Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability

Article ID	Journal	Published Year	Pages	File Type
8264901	Free Radical Biology and Medicine	2018	43 Pages	PDF

Keywords

Bcl-2 Nfr2 OCR GADPH cyto c ECAR MRC MMP-2 SRC TBARS mTOR HO-1 OXPHOS GPX EGFR CDK 5-FU HER2 ERK1/2 MAPK NF-кB ROS Akt Synergistic effect Bax Apoptosis retinoblastoma SOD Colorectal cancer Colon cancer Superoxide dismutase cytochrome c combination index Manuka honey FasL nuclear factor kappa B Oxidative phosphorylation 5-fluorouracil B-cell lymphoma-2 thiobarbituric acid-reactive substance Oxygen consumption rate extracellular acidification rate mammalian target of rapamycin heme oxygenase 1 Bcl-2 Associated X protein protein kinase B mitogen-activated protein kinase CRC extracellular-signal-regulated kinase 1/2 cyclin-dependent kinase glutathione reductase glutathione peroxidase glyceraldehyde-3-phosphate dehydrogenase Reactive oxygen species Human epidermal growth factor receptor 2 Epidermal growth factor receptor

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Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability

Authors

Sadia Afrin, Francesca Giampieri, Tamara Y. Forbes-Hernández, Massimiliano Gasparrini, Adolfo Amici, Danila Cianciosi, JosÃ¨ L. Quiles, Maurizio Battino,