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Crystal structures of the disease-causing D444V mutant and the relevant wild type human dihydrolipoamide dehydrogenase

Article ID Journal Published Year Pages File Type
8265130 Free Radical Biology and Medicine 2018 7 Pages PDF
Keywords
E3-binding proteinalpha-ketoglutarate dehydrogenase complexASUE3BPKGDHCPDHcflavin adenine dinucleotideHDX-MSRMSDTRISGCs2-amino-2-hydroxymethyl-propane-1,3-diolNAD+/NADHROSEDTAEthylenediaminetetraacetic acidHumanFADX-ray crystallographyBis-trisOxidative stressPathogenic mutationProtein structureGlycine cleavage systemLADHLipoamide dehydrogenaseLipoic acidbranched-chain α-keto acid dehydrogenase complexroot mean square deviationwild typeasymmetric unitpyruvate dehydrogenase complexReactive oxygen species
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
Preview
Crystal structures of the disease-causing D444V mutant and the relevant wild type human dihydrolipoamide dehydrogenase
Authors
Eszter Szabo, Reka Mizsei, Piotr Wilk, Zsofia Zambo, Beata Torocsik, Manfred S. Weiss, Vera Adam-Vizi, Attila Ambrus,
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Journal
Free Radical Biology and Medicine
Journal: Free Radical Biology and Medicine
Related Categories
E3-binding protein
alpha-ketoglutarate dehydrogenase complex
ASU
E3BP
KGDHC
PDHc
flavin adenine dinucleotide
HDX-MS
RMSD
TRIS
GCs
2-amino-2-hydroxymethyl-propane-1,3-diol
NAD+/NADH
ROS
EDTA
Ethylenediaminetetraacetic acid
Human
FAD
X-ray crystallography
Bis-tris
Oxidative stress
Pathogenic mutation
Protein structure
Glycine cleavage system
LADH
Lipoamide dehydrogenase
Lipoic acid
branched-chain α-keto acid dehydrogenase complex
root mean square deviation
wild type
asymmetric unit
pyruvate dehydrogenase complex
Reactive oxygen species
Ageing
Biochemistry
Biochemistry, Genetics and Molecular Biology (General)
Biophysics
Biotechnology
Cancer Research
Cell Biology
Clinical Biochemistry
Developmental Biology
Endocrinology
Genetics
Molecular Biology
Molecular Medicine
Physiology
Structural Biology
Related Journals
Neurobiology of Aging
Revista Española de Geriatría y Gerontología
Ageing Research Reviews
Archives of Gerontology and Geriatrics
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Experimental Gerontology
Journal of Geriatric Oncology
Journal of the Neurological Sciences
Maturitas
Mechanisms of Ageing and Development
Parkinsonism & Related Disorders
Redox Biology
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