Pre-drug Self-assembled Nanoparticles: Recovering activity and overcoming glutathione-associated cell antioxidant resistance against photodynamic therapy

Article ID	Journal	Published Year	Pages	File Type
8265243	Free Radical Biology and Medicine	2018	39 Pages	PDF

Keywords

CH2Cl2 DBU DTT PDT GSH TLC TME TFA CLSM DCFH-DA LMP EDC ΔΨm HOBt FBS 1O2 CH3COOH DMEM N, N-Dimethyl formamide Lysosome membrane permeabilization FCM MMP DMF O2•–DLS ADPA DMSO MTT OH•ROS Hydrogen peroxide Antioxidant superoxide anion Acridine orange glacial acetic acid Photoinduced electron transfer Singlet oxygen Tem EPR Dulbecco's minimum essential medium Photodynamic therapy dihydroethidium dichlorofluorescin diacetate Dichloromethane dithiothreitol Rh 123 Hydroxyl radical Rhodamine 123 fetal bovine serum Photosensitizer Drug activation Fluorescence Flow cytometry MALDI-TOF-MS Tumor microenvironment Laser Scanning Confocal Microscope Transmission electron microscope Self-assembled nanoparticles Mitochondrial membrane permeabilization Enhanced permeability and retention effect H2O2 DHE PET Mitochondrial membrane potential Dynamic Light Scattering thin-layer chromatography Glutathione Reactive oxygen species

Related Topics

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Pre-drug Self-assembled Nanoparticles: Recovering activity and overcoming glutathione-associated cell antioxidant resistance against photodynamic therapy

Authors

Kaikai Xu, Hai Yao, Jinhui Hu, Jiahong Zhou, Lin Zhou, Shaohua Wei,