Sodium butyrate attenuates diabetes-induced aortic endothelial dysfunction via P300-mediated transcriptional activation of Nrf2

Article ID	Journal	Published Year	Pages	File Type
8265260	Free Radical Biology and Medicine	2018	40 Pages	PDF

Keywords

HO1 3-NT VCAM-1 NQO1 NaB Nrf2 CTRL SFN MDA 4-hydroxynonenal 4-HNE NAD(P)H dehydrogenase quinone 1 ICAM-1 STZ AHR HDAC iNOS 3-nitrotyrosine keap1 ROS Aorta ACh Endothelial dysfunction streptozotocin Acetylcholine inflammation chromatin immunoprecipitation immunohistochemical IHC Diabetes Oxidative stress Diabetes mellitus Sodium butyrate Endothelial cell inducible nitric oxide synthase Sulforaphane nuclear factor erythroid 2-related factor 2 phenylephrine malondialdehyde intercellular adhesion molecule-1 vascular cell adhesion molecule-1 knockout wild type heme oxygenase 1 histone deacetylase Kelch-like ECH-associated protein 1 CHiP Control high glucose normal glucose Reactive oxygen species aryl hydrocarbon receptor

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Sodium butyrate attenuates diabetes-induced aortic endothelial dysfunction via P300-mediated transcriptional activation of Nrf2

Authors

Junduo Wu, Ziping Jiang, Haina Zhang, Wenzhao Liang, Wenlin Huang, Huan Zhang, Ying Li, Zhaohui Wang, Junnan Wang, Ye Jia, Bin Liu, Hao Wu,