Neurotoxicity of cytarabine (Ara-C) in dorsal root ganglion neurons originates from impediment of mtDNA synthesis and compromise of mitochondrial function

Article ID	Journal	Published Year	Pages	File Type
8265296	Free Radical Biology and Medicine	2018	11 Pages	PDF

Keywords

DRG 8-oxoG BER OCR GSH NADPH DDR dorsal root ganglion 6-aminonicotinamide 8-oxoguanine Mitochondrial DNA DNA polymerase γ NER NADP+ROS nucleotide excision repair base excision repair mtDNA Neurotoxicity peripheral nervous system Mitochondria Oxygen consumption rate dorsal root ganglion neurons nicotinamide adenine dinucleotide phosphate nicotinamide adenine dinucleotide phosphate, reduced form DNA damage response pol γ PNS reduced glutathione Reactive oxygen species

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Neurotoxicity of cytarabine (Ara-C) in dorsal root ganglion neurons originates from impediment of mtDNA synthesis and compromise of mitochondrial function

Authors

Ming Zhuo, Murat F. Gorgun, Ella W. Englander,