Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts

Article ID	Journal	Published Year	Pages	File Type
8265486	Free Radical Biology and Medicine	2018	12 Pages	PDF

Keywords

COL1A1 NAC GAPDH GSSG ECM N-acetyl-l-cysteine UPR eIF2α PARP DAPI PRX BH3 interacting-domain death agonist MG-H1 RPL13A ribosomal protein L13A poly(ADP-ribose)-polymerase .OH ATF4 GSH ESR 4',6-diamidino-2-phenylindole IRE1α MTT ROS Hydrogen peroxide ER stress CHOP Apoptosis Hydroxyl radical Electron spin resonance Aging Age endoplasmic reticulum activating transcription factor 4 Extracellular matrix Methylglyoxal Advanced glycation end products Redox homeostasis H2O2 Unfolded protein response CCAAT-enhancer-binding protein homologous protein Peroxiredoxin PERK advanced glycation end product BID reduced glutathione Collagen oxidized glutathione glyceraldehyde-3-phosphate dehydrogenase Reactive oxygen species

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Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts

Authors

Kerstin Nowotny, José Pedro Castro, MartÃn Hugo, Sabine Braune, Daniela Weber, Marc Pignitter, Veronika Somoza, Julia Bornhorst, Tanja Schwerdtle, Tilman Grune,