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Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis

Article ID Journal Published Year Pages File Type
8265990 Free Radical Biology and Medicine 2018 35 Pages PDF
Keywords
TFANADPH:quinone oxidoreductase 1NMPNQO-1Heme oxygenase-1DSFPPIHO-1Nrf2SARDMFLPSkeap1CDDO-MeH&En-methyl pyrrolidoneN,N-diisopropylethylamineROSTrifluoroacetic acidBardoxolone methylInhibitorSurface plasmon resonanceSPRProtein-protein interactionPAINSdimethyl fumarateStructure–activity relationshiphematoxylin and eosin stainingantioxidant response elementnuclear factor erythroid 2-related factor 2Differential scanning fluorimetryLipopolysaccharidesMyocarditisDIPEAAREKelch-like ECH-associated protein 1Reactive oxygen species
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
Preview
Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis
Authors
Ning Meng, Hua Tang, Hao Zhang, Chengshi Jiang, Li Su, Xiao Min, Wannian Zhang, Hua Zhang, Zhenyuan Miao, Wen Zhang, Chunlin Zhuang,
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Journal
Free Radical Biology and Medicine
Journal: Free Radical Biology and Medicine
Related Categories
TFA
NADPH:quinone oxidoreductase 1
NMP
NQO-1
Heme oxygenase-1
DSF
PPI
HO-1
Nrf2
SAR
DMF
LPS
keap1
CDDO-Me
H&E
n-methyl pyrrolidone
N,N-diisopropylethylamine
ROS
Trifluoroacetic acid
Bardoxolone methyl
Inhibitor
Surface plasmon resonance
SPR
Protein-protein interaction
PAINS
dimethyl fumarate
Structure–activity relationship
hematoxylin and eosin staining
antioxidant response element
nuclear factor erythroid 2-related factor 2
Differential scanning fluorimetry
Lipopolysaccharides
Myocarditis
DIPEA
ARE
Kelch-like ECH-associated protein 1
Reactive oxygen species
Ageing
Biochemistry
Biochemistry, Genetics and Molecular Biology (General)
Biophysics
Biotechnology
Cancer Research
Cell Biology
Clinical Biochemistry
Developmental Biology
Endocrinology
Genetics
Molecular Biology
Molecular Medicine
Physiology
Structural Biology
Related Journals
Neurobiology of Aging
Revista Española de Geriatría y Gerontología
Ageing Research Reviews
Archives of Gerontology and Geriatrics
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Experimental Gerontology
Journal of Geriatric Oncology
Journal of the Neurological Sciences
Maturitas
Mechanisms of Ageing and Development
Parkinsonism & Related Disorders
Redox Biology
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