Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress

Article ID	Journal	Published Year	Pages	File Type
8266069	Free Radical Biology and Medicine	2018	13 Pages	PDF

Keywords

cumulative population doubling level ALT PHE qRT-PCR LDL-C HUVECS eNOS SAMP8 HDL-C DBP SA-β-gal PAI-1 FBG EDD Media thickness EVG H-E SAMR1 CPDL ECs ROS senescence-associated β-galactosidase Hydrogen peroxide AST Aspartate aminotransferase Alanine aminotransferase ACh Acetylcholine Immunohistochemistry IHC cardiovascular disease CVD Human umbilical vein endothelial cells Endothelial cells endothelial nitric oxide synthase body mass index BMI diastolic blood pressure phenylephrine fasting blood glucose high-density lipoprotein cholesterol Plasminogen activator inhibitor-1 senescence-accelerated mouse prone 8 Nitric oxide Hematoxylin and Eosin H2O2 quantitative real-time PCR Low-density lipoprotein cholesterol Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Ageing

Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress

Authors

Yilang Ke, Dang Li, Mingming Zhao, Changjie Liu, Jia Liu, Aiping Zeng, Xiaoyun Shi, Si Cheng, Bing Pan, Lemin Zheng, Huashan Hong,