Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes

Article ID	Journal	Published Year	Pages	File Type
8266174	Free Radical Biology and Medicine	2018	31 Pages	PDF

Keywords

ATB BSEP PRA ATF6 FLX eIF2α PBA Mrp2 PHH dichlorodihydrofluorescein Hsp 4-phenyl butyric acid NAC TCA NaF H2-DCFDA CDFDA AMP CDF methylthiazoletetrazolium CLX LVX PBS PI3K protein kinase RNA (PKR)-like ER kinase Ac-DEVD-AMC DMSO primary human hepatocytes IRE1α MTT N-acetyl-cysteine Drug-induced liver injury Ampicillin Antibiotic Akt Ery Erythromycin Taurocholic acid DILI Dimethyl sulfoxide endoplasmic reticulum eukaryotic initiation factor 2 Phosphate buffered saline phosphatidylinositol-3-kinase activating transcription factor 6 Flucloxacillin Levofloxacin Nafcillin Heat shock protein multidrug resistance-associated protein 2 protein kinase B PERK Bile salt export pump bile canaliculi Cloxacillin

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Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes

Authors

Audrey Burban, Ahmad Sharanek, Christiane Guguen-Guillouzo, André Guillouzo,