The 3-phenylcoumarin derivative 6,7-dihydroxy-3-[3â²,4â²-methylenedioxyphenyl]-coumarin downmodulates the FcÎ³R- and CR-mediated oxidative metabolism and elastase release in human neutrophils: Possible mechanisms underlying inhibition of the formation a

Article ID	Journal	Published Year	Pages	File Type
8266368	Free Radical Biology and Medicine	2018	61 Pages	PDF

Keywords

GPCR 5-fluoro-2-indolyl des-chlorohalopemide FIPI FPR1 luminol-enhanced chemiluminescence N-formyl-methionyl-leucyl-phenylalanine fMLP FcγR Phorbol-12-myristate-13-acetate NHS PKC DPI HBSS DAPI NADPH IC50 PBS MFI FITC 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide 4-aminobenzoic acid hydrazide MPO DMSO PMA MTT NETs ROS ABAH Elastase analysis of variance ANOVA neutrophil extracellular trap neutrophil extracellular traps tumor necrosis factor-α Docking diphenyleneiodonium chloride Dimethyl sulfoxide normal human serum median fluorescence intensity lucigenin-enhanced chemiluminescence TNF-α phycoerythrin reduced form of nicotinamide adenine dinucleotide phosphate Phosphate buffered saline fluorescein isothiocyanate lactate dehydrogenase LDH immune complex Hank's balanced salt solution myeloperoxidase Protein kinase C Reactive oxygen species Fcγ receptor Complement receptor G protein-coupled receptor

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The 3-phenylcoumarin derivative 6,7-dihydroxy-3-[3â²,4â²-methylenedioxyphenyl]-coumarin downmodulates the FcÎ³R- and CR-mediated oxidative metabolism and elastase release in human neutrophils: Possible mechanisms underlying inhibition of the formation a

Authors

Micássio F. Andrade, Luciana M. Kabeya, Leandro O. Bortot, Gabriela B. dos Santos, Everton O.L. Santos, Lucinéia R. Albiero, Andréa S.G. Figueiredo-Rinhel, Camila A. Carvalho, Ana Elisa C.S. Azzolini, Antonio Caliri, MÃ´nica T. Pupo, Flavio S. Emery,