Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease

Article ID	Journal	Published Year	Pages	File Type
8266450	Free Radical Biology and Medicine	2018	54 Pages	PDF

Keywords

Rcan1 PSEN1 cdk5 IPSCs ILV DYRK1A UPR LC3 SOD1 LBPA MAPT Regulator of Calcineurin 1 ESCRT GEF MVB VPS BFCN Autophagosome V-ATPase Hsa21 GDI SYN1 CSTB Aβ mTOR LCLS APPL1 CTSD APP SNX Cystatin B GDF GSK-3β NGF Vacuolar ATPase presenilin 1 amyloid-β Autophagy Lyso-bisphosphatidic acid Endosomes GDP dissociation inhibitor multivesicular body Alzheimer's disease Alzheimer disease Trk lymphoblastoid cell lines Induced pluripotent stem cells Down syndrome superoxide dismutase 1 cyclin-dependent kinase 5 GAP guanine nucleotide exchange factor nerve growth factor phosphoinositide 3-kinase Lysosomes Sorting nexin Vacuolar protein sorting basal forebrain cholinergic neurons mammalian target of rapamycin Unfolded protein response GTPase-activating protein microtubule-associated protein tau microtubule-associated protein 1A/1B-light chain 3 amyloid precursor protein cathepsin D Chromosome 21 mouse chromosome 16 Glycogen synthase kinase 3β tropomyosin receptor kinase

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Ageing

Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease

Authors

Daniel J. Colacurcio, Anna Pensalfini, Ying Jiang, Ralph A. Nixon,