Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells

Article ID	Journal	Published Year	Pages	File Type
8266560	Free Radical Biology and Medicine	2017	14 Pages	PDF

Keywords

MRP1 K-Ras ABC B-Raf NQO-1 ABCC1 AREs GCLC tert-butylhydroquinone TAC GCLM RT-qPCR ABCC Topoisomerase II nuclear factor erythroid-2-related factor 2 GSH AKR1C1 shRNA HO1 Nrf2 t-BHQ Txnrd1 Kelch-like ECH associating protein 1 Prdx1 AHR B-Raf proto-oncogene, serine/threonine kinase keap1 c-Myc NAD(P)H:quinone oxidoreductase short hairpin RNA siRNA t-BOOH Hydrogen peroxide standard deviation chromatin immunoprecipitation small interference RNA tert-Butyl-hydroperoxide Thioredoxin reductase 1 Real-time RT-PCR Total antioxidant capacity Acquired resistance H2O2 histone acetyltransferases Peroxiredoxin 1 Multidrug Resistance-associated Protein 1 CHiP HATs ATP-binding cassette Glutathione glutathione (reduced form)glutathione reductase aryl hydrocarbon receptor

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Life Sciences Biochemistry, Genetics and Molecular Biology Ageing

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Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells

Authors

Huang-Hui Chen, Hsin-Huei Chang, Jang-Yang Chang, Ya-Chu Tang, Yung-Chi Cheng, Li-Mei Lin, Shu-Ying Cheng, Chih-Hsiang Huang, Man-Wu Sun, Chiung-Tong Chen, Ching-Chuan Kuo,