Impaired Nrf2 regulation of mitochondrial biogenesis in rostral ventrolateral medulla on hypertension induced by systemic inflammation

- Systemic inflammation induces impairment of mitochondrial biogenesis and bioenergetics in rostral ventrolateral medulla (RVLM) where sympathetic premotor neurons reside.
- Impairment of mitochondrial biogenesis results from the redox-sensitive and IL-1β-dependent suppression of nuclear translocation of the activated Nrf2.
- Defect Nrf2 nuclear translocation reduces mitochondrial biogenesis through decrease in Nrf2 binding to Tfam promoter.
- Impaired Nrf-2-regulated mitochondrial biogenesis in RVLM contributes to hypertension under systemic inflammation.