Propofol but not sevoflurane prevents mitochondrial dysfunction and oxidative stress by limiting HIF-1Î± activation in hepatic ischemia/reperfusion injury

Article ID	Journal	Published Year	Pages	File Type
8267819	Free Radical Biology and Medicine	2016	11 Pages	PDF

Keywords

SEVO HNE BNIP3 FRL Heme oxygenase-1 HIF-1α DFX PTP ALT PROP GSSG TfR1 HO-1 7-AAD Deferoxamine DMEM GSH 7-amino-actinomycin D RCI Sevoflurane 4-hydroxy-2-nonenal DMSO I/R Dulbecco's modified Eagle's medium MTT ROS Δψ AST Aspartate aminotransferase Alanine aminotransferase Annexin V Permeability transition pore standard deviation of the mean CSA ischemia/reperfusion Anesthetics analysis of variance ANOVA Apoptosis Dimethyl sulfoxide cyclosporin A Respiratory control index hypoxia-inducible factor 1 alpha SDM Liver mitochondria Hydroperoxide H2O2 Mitochondrial membrane potential Propofol reduced glutathione oxidized glutathione Reactive oxygen species

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Propofol but not sevoflurane prevents mitochondrial dysfunction and oxidative stress by limiting HIF-1Î± activation in hepatic ischemia/reperfusion injury

Authors

Francesco Bellanti, Lucia Mirabella, Domenica Mitarotonda, Maria Blonda, Rosanna Tamborra, Gilda Cinnella, Alberto Fersini, Antonio Ambrosi, Michele Dambrosio, Gianluigi Vendemiale, Gaetano Serviddio,