Intracellular labile iron determines H2O2-induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis

Article ID	Journal	Published Year	Pages	File Type
8267823	Free Radical Biology and Medicine	2016	36 Pages	PDF

Keywords

Mitogen activated protein kinases (MAPKs)Trx ASK1 c-Jun NH2-terminal kinase Desferrioxamine SIH PRX LIP ERK HUVECS GPX N-ethylmaleimide DFO TFR PARP-1 Jnk MAPK Mitogen activated protein kinases Hydrogen peroxide Labile iron Acridine orange Labile iron pool thioredoxin Apoptosis Human umbilical vein endothelial cells Redox signaling NEM Peroxiredoxin extracellular-signal-regulated kinase apoptosis signal-regulating kinase 1 glutathione peroxidase transferrin receptor

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Intracellular labile iron determines H2O2-induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis

Authors

M.D. Mantzaris, S. Bellou, V. Skiada, N. Kitsati, T. Fotsis, D. Galaris,