Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy

Article ID	Journal	Published Year	Pages	File Type
8268100	Free Radical Biology and Medicine	2016	28 Pages	PDF

Keywords

TGF-β PKC IL-10 CRF NF-kB 3-MA HO-1 Heme oxygenase-1 GPX Nrf2 NOS2 NQO1 IL-6 LPS ARG-1 UUO keap1 MAPK ROS Rheumatoid arthritis Arginase-1 inflammation Unilateral ureteral obstruction Interleukin-10 interleukin-6 Interleukin-1β sin chronic kidney disease Transforming growth factor β tumor necrosis factor-α renoprotection SOD Superoxide dismutase Sinomenine Nuclear factor-kB lipopolysaccharide Macrophages CKD Chronic renal failure obstructive nephropathy nitric oxide synthase 2 Hematoxylin and Eosin Protein kinase C mitogen-activated protein kinase Chloroquine glutathione peroxidase Reactive oxygen species

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Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy

Authors

Tian Qin, Ronghui Du, Fengjie Huang, Shasha Yin, Jun Yang, Siyuan Qin, Wangsen Cao,