Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1

Article ID	Journal	Published Year	Pages	File Type
8268105	Free Radical Biology and Medicine	2016	32 Pages	PDF

Keywords

27-OHC ECM CyP NVU CHM Cytochrome P450 (CYP)MMP 24(S)-Hydroxycholesterol 25-OH-D3 1,25-dihydroxyvitamin D3 25-hydroxyvitamin D3 27-Hydroxycholesterol CCm ROS Arachidonic acid epoxyeicosatrienoic acids Cerebrovascular disease Oxidative stress EET intracerebral hemorrhage Free radicals Blood–brain barrier BBB Cytochrome P450 Disease severity Leukotrienes Extracellular matrix matrix metalloproteinase Matrix metalloproteinase (MMP)ICH Cerebral cavernous malformation neurovascular unit Prostaglandins Single nucleotide polymorphism SNP Reactive oxygen species (ROS)Reactive oxygen species

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Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1

Authors

HélÃ¨ne Choquet, Eliana Trapani, Luca Goitre, Lorenza Trabalzini, Amy Akers, Marco Fontanella, Blaine L. Hart, Leslie A. Morrison, Ludmila Pawlikowska, Helen Kim, Saverio Francesco Retta,