Osthol attenuates neutrophilic oxidative stress and hemorrhagic shock-induced lung injury via inhibition of phosphodiesterase 4

Article ID	Journal	Published Year	Pages	File Type
8268565	Free Radical Biology and Medicine	2015	29 Pages	PDF

Keywords

t/h pKa PDE ERK GPCR PGE FPR ARDS fMLP Jnk 2-OH-E+2-hydroxyethidium c-Jun N-terminal kinase cAMP MPO G-protein-coupled receptor MAPK ROS cyclic adenosine 3′,5′-monophosphate adenylate cyclase Acute lung injury Akt Ali Osthol COPD Chronic obstructive pulmonary disease Free radicals Acute respiratory distress syndrome Hemorrhagic shock Phosphodiesterase phosphodiesterase 4 inhibitor lactate dehydrogenase LDH myeloperoxidase neutrophil protein kinase A protein kinase B mitogen-activated protein kinase prostaglandin E extracellular signal-regulated kinase Reactive oxygen species formyl peptide receptor

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Osthol attenuates neutrophilic oxidative stress and hemorrhagic shock-induced lung injury via inhibition of phosphodiesterase 4

Authors

Yung-Fong Tsai, Huang-Ping Yu, Pei-Jen Chung, Yann-Lii Leu, Liang-Mou Kuo, Chun-Yu Chen, Tsong-Long Hwang,