Macrophage migration inhibitory factor (MIF) is rendered enzymatically inactive by myeloperoxidase-derived oxidants but retains its immunomodulatory function

Article ID	Journal	Published Year	Pages	File Type
8268617	Free Radical Biology and Medicine	2015	36 Pages	PDF

Keywords

HOCl SCN−phorbol 12-myristate 13-acetate PBMCs HBSS DPI HPP LPS FBS MPO l-methionine PMA Hydrogen peroxide hypochlorous acid inflammation Thiocyanate Apoptosis Diphenyleneiodonium fetal bovine serum peripheral blood mononuclear cells Cytokine MIF Macrophage migration inhibitory factor Macrophage migration inhibitory factor (MIF)lipopolysaccharide Hank's balanced salt solution MET IAM myeloperoxidase Myeloperoxidase (MPO)neutrophil H2O2 Propidium iodide Carbamylation Taurine chloramine iodoacetamide

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Macrophage migration inhibitory factor (MIF) is rendered enzymatically inactive by myeloperoxidase-derived oxidants but retains its immunomodulatory function

Authors

Nina Dickerhof, Lisa Schindler, Jürgen Bernhagen, Anthony J. Kettle, Mark B. Hampton,