Combined aerobic exercise and enzyme replacement therapy rejuvenates the mitochondrial-lysosomal axis and alleviates autophagic blockage in Pompe disease

Article ID	Journal	Published Year	Pages	File Type
8268714	Free Radical Biology and Medicine	2015	46 Pages	PDF

Keywords

OMM CI-MPR rhGAA AET LSD Infantile-onset Pompe disease IOPD GAA PGC-1α mTOR LOPD peroxisome proliferator-activated receptor gamma coactivator 1-alpha AUC enzyme replacement therapy Autophagy Lysosomal storage disorder Acid α-glucosidase Fatty acid Exocytosis adult Late-onset Pompe disease Lysosomal storage disease Neurodegenerative disease aerobic exercise training Aging outer mitochondrial membrane Lipofuscin MET area under the curve Fog Infantile Glycogen storage disease type II wild type mammalian target of rapamycin ERT Clear cation-independent mannose-6-phosphate receptor Ubiquitin

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Combined aerobic exercise and enzyme replacement therapy rejuvenates the mitochondrial-lysosomal axis and alleviates autophagic blockage in Pompe disease

Authors

M.I. Nilsson, L.G. MacNeil, Y. Kitaoka, R. Suri, S.P. Young, J.J. Kaczor, N.J. Nates, M.U. Ansari, T. Wong, M. Ahktar, L. Brandt, B.P. Hettinga, M.A. Tarnopolsky,