Perfluorooctanoic acid exposure induces endoplasmic reticulum stress in the liver and its effects are ameliorated by 4-phenylbutyrate

Article ID	Journal	Published Year	Pages	File Type
8268827	Free Radical Biology and Medicine	2015	47 Pages	PDF

Keywords

Cyp4a10 eIF2α LC3 SOD1 N-acetyl-l-cysteine ACOX1 SOD2 PPAR LPL SREBP HMGCR SCD1 18S FABP1 NAC 4-PBA RAPA CAT XBP1S PFOA sequestosome 1 3-Hydroxy-3-Methylglutaryl-coenzyme A reductase C/EBP homologous protein Small interfering RNA 18S ribosomal RNA ROS siRNA VLDLR Liver injury Stearoyl-coenzyme A desaturase 1 ER stress Endoplasmic reticulum stress fatty acid synthase Oxidative stress CHOP Rapamycin microtubule-associated protein light chain 3 Sodium 4-phenylbutyrate Hepatotoxicity superoxide dismutase 1 Superoxide dismutase 2 Cytochrome P450 eukaryotic initiation factor 2α Fasn Lipoprotein lipase Lipid metabolism Srebf Perfluorooctanoic acid sterol regulatory element binding protein Catalase Chloroquine Reactive oxygen species peroxisome proliferator-activated receptor Very low density lipoprotein receptor

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Perfluorooctanoic acid exposure induces endoplasmic reticulum stress in the liver and its effects are ameliorated by 4-phenylbutyrate

Authors

Shengmin Yan, Hongxia Zhang, Jianshe Wang, Fei Zheng, Jiayin Dai,