MPTP activates ASK1-p38 MAPK signaling pathway through TNF-dependent Trx1 oxidation in parkinsonism mouse model

Article ID	Journal	Published Year	Pages	File Type
8268837	Free Radical Biology and Medicine	2015	48 Pages	PDF

Keywords

TNFR FADD DJ1 MCP1 pp38 phosphorylated p38 Parkinson′s disease ADAM17 ASK1 IL6 IFNγ IL10 6-OHDA MAP3K TRAF TRADD IL12 ADAM metallopeptidase domain 17 PARK7 CIB1 GRX1 PCNA TNF SDS Jnk DTT GSTM1 6-Hydroxydopamine AMS c-Jun N-terminal kinase MAPK MKK ROS SNpc Trx1 γ-amino butyric acid Striatum interferon-γ interleukin-12 Interleukin-10 interleukin-6 Oxidative stress substantia nigra pars compacta Neurodegeneration tumor necrosis factor-α Thioredoxin 1 Thiols dithiothreitol sodium dodecyl sulfate TNF receptor associated factor Cell death Graph theory tub monocyte chemoattractant protein 1 Fas-associated protein with death domain mitogen-activated protein kinase mitogen-activated protein kinase kinase mitogen-activated protein kinase kinase kinase post-nuclear supernatant PNS apoptosis signal-regulating kinase 1 GABA Glutaredoxin 1 Reactive oxygen species TNF receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Ageing

MPTP activates ASK1-p38 MAPK signaling pathway through TNF-dependent Trx1 oxidation in parkinsonism mouse model

Authors

Ajit Ray, Neha Sehgal, Smitha Karunakaran, Govindan Rangarajan, Vijayalakshmi Ravindranath,