COX-2 is involved in vascular oxidative stress and endothelial dysfunction of renal interlobar arteries from obese Zucker rats

Proposed mechanisms for COX-2- and ROS-induced renal endothelial dysfunction in obesity. See Discussion for details. AA, arachidonic acid; ACh, acetylcholine, COX-1, cyclooxygenase 1; COX-2, cyclooxygenase 2; EC, endothelial cell; eNOS, endothelial nitric oxide synthase; IP, Prostacyclin receptor; NO, nitric oxide; PGI2, prostacyclin; TXA2, thromboxane A2; TP, TXA2/PGH2 receptor; VSMC, vascular smooth muscle cell. Inhibition of contraction240