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The overexpression and nuclear translocation of Trx-1 during hypoxia confers on HepG2 cells resistance to DDP, and GL-V9 reverses the resistance by suppressing the Trx-1/Ref-1 axis

Article ID Journal Published Year Pages File Type
8269323 Free Radical Biology and Medicine 2015 44 Pages PDF
Keywords
TIGARLDHADDPTrx-1SCO2TP53-induced glycolysis and apoptosis regulatorHKIIHIF-1αPDHK1ROSThioredoxin-1Free radicalscisplatinhypoxia-inducible factor-1αLactate dehydrogenase AreverseDrug resistancehexokinase IIPyruvate dehydrogenase kinase 1Reactive oxygen species
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
Preview
The overexpression and nuclear translocation of Trx-1 during hypoxia confers on HepG2 cells resistance to DDP, and GL-V9 reverses the resistance by suppressing the Trx-1/Ref-1 axis
Authors
Li Zhao, Wei Li, Yuxin Zhou, Yi Zhang, Shaoliang Huang, Xuefen Xu, Zhiyu Li, Qinglong Guo,
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Journal
Free Radical Biology and Medicine
Journal: Free Radical Biology and Medicine
Related Categories
TIGAR
LDHA
DDP
Trx-1
SCO2
TP53-induced glycolysis and apoptosis regulator
HKII
HIF-1α
PDHK1
ROS
Thioredoxin-1
Free radicals
cisplatin
hypoxia-inducible factor-1α
Lactate dehydrogenase A
reverse
Drug resistance
hexokinase II
Pyruvate dehydrogenase kinase 1
Reactive oxygen species
Ageing
Biochemistry
Biochemistry, Genetics and Molecular Biology (General)
Biophysics
Biotechnology
Cancer Research
Cell Biology
Clinical Biochemistry
Developmental Biology
Endocrinology
Genetics
Molecular Biology
Molecular Medicine
Physiology
Structural Biology
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Revista Española de Geriatría y Gerontología
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