Ferritin-stimulated lipid peroxidation, lysosomal leak, and macroautophagy promote lysosomal “metastability” in primary hepatocytes determining in vitro cell survival

Article ID	Journal	Published Year	Pages	File Type
8269521	Free Radical Biology and Medicine	2015	11 Pages	PDF

Keywords

GSH DAPI LMP LEU LC3 GSSG ELC 3-MA HNE ACD DFO PCD RFL TFR RME GFL EGF Mitochondrial outer membrane permeability PI3K Desferrioxamine mesylate 3-methyladenine 4′,6-diamidino-2-phenylindole 4-hydroxy-2-nonenal Hepatocytes ROS Acridine orange Autophagy Receptor-mediated endocytosis Immunofluorescence minimum essential medium Conditioned medium epidermal growth factor Ferritin phosphoinositide-3-kinase leupeptin Lysosome MEM MOMP Programmed cell death Cell death glutathione (reduced form)oxidized glutathione Reactive oxygen species transferrin receptor

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Ferritin-stimulated lipid peroxidation, lysosomal leak, and macroautophagy promote lysosomal “metastability” in primary hepatocytes determining in vitro cell survival

Authors

Margit A. Krenn, Melanie Schürz, Bernhard Teufl, Koji Uchida, Peter M. Eckl, Nikolaus Bresgen,