Binge alcohol promotes hypoxic liver injury through a CYP2E1-HIF-1Î±-dependent apoptosis pathway in mice and humans

Article ID	Journal	Published Year	Pages	File Type
8269818	Free Radical Biology and Medicine	2014	12 Pages	PDF

Keywords

mitochondrial aldehyde dehydrogenase 2 ALDH2 3-NT BNIP3 HIF-1α ALT iNOS ADH CYP2E1 NIAAA CAT 3-nitrotyrosine BAC ALD Alanine aminotransferase Binge ethanol Alcohol dehydrogenase terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling alcoholic liver disease TUNEL Apoptosis Free radicals inducible nitric oxide synthase cytochrome P450 2E1 body mass index BMI hypoxia-inducible factor-1α Blood alcohol concentration National Institute on Alcohol Abuse and Alcoholism wild type Protein nitration Hypoxia Catalase

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Binge alcohol promotes hypoxic liver injury through a CYP2E1-HIF-1Î±-dependent apoptosis pathway in mice and humans

Authors

Jun-Won Yun, Min-Jeong Son, Mohamed A. Abdelmegeed, Atrayee Banerjee, Timothy R. Morgan, Seong-Ho Yoo, Byoung-Joon Song,