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Mitochondrial thioredoxin reductase inhibition, selenium status, and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds

Article ID Journal Published Year Pages File Type
8270135 Free Radical Biology and Medicine 2014 36 Pages PDF
Keywords
TrxR1SECISTRX2TrxR2mercuric mercurySECNRF-2VDACmRNAMeHgGAPDHNADPHGSHGPXBSAHg2+ROSsEHTrx1bovine serum albuminthioredoxin reductaseSelenocysteine insertion sequencethioredoxinMercuryFree radicalsSeleniumantioxidant-response elementnuclear factor erythroid 2-related factor 2MethylmercuryMitochondrianicotinamide adenine dinucleotide phosphateAREThiol groupglutathione (reduced form)glutathione reductaseglutathione peroxidaseglyceraldehyde 3-phosphate dehydrogenaseReactive oxygen species
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
Preview
Mitochondrial thioredoxin reductase inhibition, selenium status, and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds
Authors
Vasco Branco, Ana Godinho-Santos, João Gonçalves, Jun Lu, Arne Holmgren, Cristina Carvalho,
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Journal
Free Radical Biology and Medicine
Journal: Free Radical Biology and Medicine
Related Categories
TrxR1
SECIS
TRX2
TrxR2
mercuric mercury
SEC
NRF-2
VDAC
mRNA
MeHg
GAPDH
NADPH
GSH
GPX
BSA
Hg2+
ROS
sEH
Trx1
bovine serum albumin
thioredoxin reductase
Selenocysteine insertion sequence
thioredoxin
Mercury
Free radicals
Selenium
antioxidant-response element
nuclear factor erythroid 2-related factor 2
Methylmercury
Mitochondria
nicotinamide adenine dinucleotide phosphate
ARE
Thiol group
glutathione (reduced form)
glutathione reductase
glutathione peroxidase
glyceraldehyde 3-phosphate dehydrogenase
Reactive oxygen species
Ageing
Biochemistry
Biochemistry, Genetics and Molecular Biology (General)
Biophysics
Biotechnology
Cancer Research
Cell Biology
Clinical Biochemistry
Developmental Biology
Endocrinology
Genetics
Molecular Biology
Molecular Medicine
Physiology
Structural Biology
Related Journals
Neurobiology of Aging
Revista Española de Geriatría y Gerontología
Ageing Research Reviews
Archives of Gerontology and Geriatrics
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Experimental Gerontology
Journal of Geriatric Oncology
Journal of the Neurological Sciences
Maturitas
Mechanisms of Ageing and Development
Parkinsonism & Related Disorders
Redox Biology
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