Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8270206 | Free Radical Biology and Medicine | 2014 | 65 Pages |
Abstract
Genetic manipulation or activation through natural or chemical compounds of various components of the UPS system (e.g. proteasome subunits, E2 and E3 ligases, DUBs) have been revealed to affect the UPS function in cellular models (primary cultures of mammalian origins) as well as in yeast, nematode worms, flies, rodents and humans in terms of proteasome activities and/or assembly and/or expression. UPS activation has been shown to result to extended cellular viability, lifespan extension and resistance to stress.173
Keywords
CT-LT-LPGPHInsulin/IGF-1 signaling pathwayLongevity regulationIISAMDamyotrophic lateral sclerosisAlzheimer diseaseALSHuntington diseaseParkinson diseaseFree radicalsAgingage-related macular degenerationubiquitin–proteasome systemantioxidant-response elementTrypsin-likeChymotrypsin-likedietary restrictioncaloric restrictionMultiple sclerosisARESenescenceUPS
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Authors
Niki Chondrogianni, Marianthi Sakellari, Maria Lefaki, Nikoletta Papaevgeniou, Efstathios S. Gonos,