| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8270971 | Free Radical Biology and Medicine | 2013 | 11 Pages |
Abstract
⺠Adaptation to hypoxia has evolved over billions of years. ⺠HIF prolyl hydroxylases are sensors of hypoxia. ⺠Antioxidant “metal chelators” inhibit HIF prolyl hydroxylases. ⺠Prolyl hydroxylase inhibitors prevent death via HIF-dependent and independent paths. ⺠Prolyl hydroxylase inhibitors prevent ferroptosis and stroke.
Keywords
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Authors
Rachel E. Speer, Saravanan S. Karuppagounder, Manuela Basso, Sama F. Sleiman, Amit Kumar, David Brand, Natalya Smirnova, Irina Gazaryan, Soah J. Khim, Rajiv R. Ratan,