| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8270990 | Free Radical Biology and Medicine | 2013 | 5 Pages |
Abstract
⺠Brief, transient expression of RCAN1 proteins promotes oxidative-stress adaptation. ⺠Chronic RCAN1-1L overexpression can promote neurodegeneration and neuronal death. ⺠RCAN1-1L-induced tau hyperphosphorylation may stimulate neurodegeneration. ⺠RCAN1-1L-induced mitochondrial dysfunction may stimulate neurodegeneration. ⺠Animals chronically overexpressing RCAN1-1L may be useful Alzheimer models.
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Authors
Gennady Ermak, Kelvin J.A. Davies,